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Cantharidin‐Based Small Molecules as Potential Therapeutic Agents

Identifieur interne : 001240 ( Main/Exploration ); précédent : 001239; suivant : 001241

Cantharidin‐Based Small Molecules as Potential Therapeutic Agents

Auteurs : Carlos E. Puerto Galvis [Colombie] ; Leonor Y. Vargas Méndez [Colombie] ; Vladimir V. Kouznetsov [Colombie]

Source :

RBID : ISTEX:09C0227772F74243786DE7E08C8F4752B86FFE06

English descriptors

Abstract

Chemical and pharmacological information on cantharidin‐based small molecules was analyzed. The review summarizes new facts about blister beetles' metabolites for the period 2006–2012. General synthetic approaches to cantharidin‐based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.
Chemical and pharmacological information on cantharidin‐based SMs was analyzed. The review summarizes new facts about blister beetles metabolites for the period 2006–2012. General synthetic approaches to cantharidin‐based small molecules as well as its chemical transformations and potential biological applications were discussed in this mini review that could help to design new SMs modulators from other biological models.

Url:
DOI: 10.1111/cbdd.12180


Affiliations:


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Le document en format XML

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<div type="abstract">Chemical and pharmacological information on cantharidin‐based small molecules was analyzed. The review summarizes new facts about blister beetles' metabolites for the period 2006–2012. General synthetic approaches to cantharidin‐based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.</div>
<div type="abstract">Chemical and pharmacological information on cantharidin‐based SMs was analyzed. The review summarizes new facts about blister beetles metabolites for the period 2006–2012. General synthetic approaches to cantharidin‐based small molecules as well as its chemical transformations and potential biological applications were discussed in this mini review that could help to design new SMs modulators from other biological models.</div>
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