Cantharidin‐Based Small Molecules as Potential Therapeutic Agents
Identifieur interne : 001240 ( Main/Exploration ); précédent : 001239; suivant : 001241Cantharidin‐Based Small Molecules as Potential Therapeutic Agents
Auteurs : Carlos E. Puerto Galvis [Colombie] ; Leonor Y. Vargas Méndez [Colombie] ; Vladimir V. Kouznetsov [Colombie]Source :
- Chemical Biology & Drug Design [ 1747-0277 ] ; 2013-11.
English descriptors
- Teeft :
- Acid core, Active molecule, Acute toxicity, Adduct, Amine, Amino acids, Analog, Analogue, Ancient medicine, Anhydride, Anhydride rings, Anticancer, Anticancer activities, Anticancer activity, Antitumor activities, Aromatic amines, Beetle, Bioavailability, Biochemical transformation, Biol, Biological activities, Biological evaluation, Biological functions, Biological role, Bioorg, Blister, Blister beetle, Blister beetles, Boric acid, Butea frondosa, Cancer treatment, Cantharidimide, Cantharidimide analogs, Cantharidimide derivatives, Cantharidin, Cantharidin analogs, Cantharidin analogues, Cantharimide, Cantharimides, Carbonyl functions, Carcinoma, Cell cycle control, Cell death, Chem, Chem biol drug, Chem lett, Chemical basis, Chemical structure, Chemical transformations, Chemotherapeutic agents, Chen chang, Colorectal cancer cells, Corresponding adducts, Crystal structures, Current strategies, Cyclic lactone, Cycloaddition, Cycloaddition adducts, Cycloaddition reaction, Dehydrative condensation, Derivative, Diene, Diethyl ether, Different types, Diverse libraries, Double bond, Drug design, Drug discovery, Embryo model, Enzymatic reactions, Excellent yields, Exchangeable points, Family meloidae, Furan, Furan derivatives, Furan ring, Furan rings, Further investigations, Further relationship studies, Galvis, Gastrointestinal tract, Good yields, Heptane core, High doses, High pressure, Hill stewart sauer, Hydroxyl groups, Important role, Industrial university, Inhibitor, Inhibitory activity, Ionic liquids, Isoprene units, Kinase, Kouznetsov, Less toxicity, Life cycle, Lytta vesicatoria, Main objective, Maleic, Maleic anhydride, Mccluskey, Meloidae, Meloidae family, Methodology, Mica organica, Microwave irradiation, Mini review, Molecule, Mylabris, Mylabris phalerate pallas, Natural derivatives, Natural molecules, Natural products, Natural source, Natural sources, Nctd, Nctd analogs, Nctd derivatives, Negative impact, Nitrogen atom, Norcantharidimide analogs, Norcantharidimide synthesis, Norcantharidin, Norcantharidin analogs, Norcantharidin analogues, Norcantharidin derivatives, Norcantharimide, Norcantharimide analogs, Organic chemistry, Other derivatives, Otis tarda, Palasonin, Pharmacological, Pharmacological information, Phosphatase, Phosphate group, Phosphoprotein phosphatases, Poisoning, Poor diene, Poor yields, Possible biosynthesis, Pp2a, Previous works, Primary amines, Proc natl acad, Protein kinases, Protein phosphatase, Protein phosphatase inhibitors, Protein phosphatases, Protein phosphorylation, Protein process, Puerto galvis, Rare earth ions, Reaction conditions, Recent studies, Renal toxicity, Room temperature, Russian peoples friendship university, Sakoff, Sakoff mccluskey, Same authors, Same conditions, Same reaction conditions, Secondary metabolites, Small molecule inhibitors, Small molecules, Small molecules figure, Solid dispersion, Solubility, Synthesis, Synthetic approach, Synthetic approaches, Tamelen friedman busgstahler, Thiophen, Total synthesis, Toxicity, Toxicological properties, Tumor cell line, Uorinated maleic anhydrides, Wang, Wide range.
Abstract
Chemical and pharmacological information on cantharidin‐based small molecules was analyzed. The review summarizes new facts about blister beetles' metabolites for the period 2006–2012. General synthetic approaches to cantharidin‐based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.
Chemical and pharmacological information on cantharidin‐based SMs was analyzed. The review summarizes new facts about blister beetles metabolites for the period 2006–2012. General synthetic approaches to cantharidin‐based small molecules as well as its chemical transformations and potential biological applications were discussed in this mini review that could help to design new SMs modulators from other biological models.
Url:
DOI: 10.1111/cbdd.12180
Affiliations:
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Le document en format XML
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<term>Active molecule</term>
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<term>Adduct</term>
<term>Amine</term>
<term>Amino acids</term>
<term>Analog</term>
<term>Analogue</term>
<term>Ancient medicine</term>
<term>Anhydride</term>
<term>Anhydride rings</term>
<term>Anticancer</term>
<term>Anticancer activities</term>
<term>Anticancer activity</term>
<term>Antitumor activities</term>
<term>Aromatic amines</term>
<term>Beetle</term>
<term>Bioavailability</term>
<term>Biochemical transformation</term>
<term>Biol</term>
<term>Biological activities</term>
<term>Biological evaluation</term>
<term>Biological functions</term>
<term>Biological role</term>
<term>Bioorg</term>
<term>Blister</term>
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<term>Blister beetles</term>
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<term>Butea frondosa</term>
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<term>Cantharidimide</term>
<term>Cantharidimide analogs</term>
<term>Cantharidimide derivatives</term>
<term>Cantharidin</term>
<term>Cantharidin analogs</term>
<term>Cantharidin analogues</term>
<term>Cantharimide</term>
<term>Cantharimides</term>
<term>Carbonyl functions</term>
<term>Carcinoma</term>
<term>Cell cycle control</term>
<term>Cell death</term>
<term>Chem</term>
<term>Chem biol drug</term>
<term>Chem lett</term>
<term>Chemical basis</term>
<term>Chemical structure</term>
<term>Chemical transformations</term>
<term>Chemotherapeutic agents</term>
<term>Chen chang</term>
<term>Colorectal cancer cells</term>
<term>Corresponding adducts</term>
<term>Crystal structures</term>
<term>Current strategies</term>
<term>Cyclic lactone</term>
<term>Cycloaddition</term>
<term>Cycloaddition adducts</term>
<term>Cycloaddition reaction</term>
<term>Dehydrative condensation</term>
<term>Derivative</term>
<term>Diene</term>
<term>Diethyl ether</term>
<term>Different types</term>
<term>Diverse libraries</term>
<term>Double bond</term>
<term>Drug design</term>
<term>Drug discovery</term>
<term>Embryo model</term>
<term>Enzymatic reactions</term>
<term>Excellent yields</term>
<term>Exchangeable points</term>
<term>Family meloidae</term>
<term>Furan</term>
<term>Furan derivatives</term>
<term>Furan ring</term>
<term>Furan rings</term>
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<term>Further relationship studies</term>
<term>Galvis</term>
<term>Gastrointestinal tract</term>
<term>Good yields</term>
<term>Heptane core</term>
<term>High doses</term>
<term>High pressure</term>
<term>Hill stewart sauer</term>
<term>Hydroxyl groups</term>
<term>Important role</term>
<term>Industrial university</term>
<term>Inhibitor</term>
<term>Inhibitory activity</term>
<term>Ionic liquids</term>
<term>Isoprene units</term>
<term>Kinase</term>
<term>Kouznetsov</term>
<term>Less toxicity</term>
<term>Life cycle</term>
<term>Lytta vesicatoria</term>
<term>Main objective</term>
<term>Maleic</term>
<term>Maleic anhydride</term>
<term>Mccluskey</term>
<term>Meloidae</term>
<term>Meloidae family</term>
<term>Methodology</term>
<term>Mica organica</term>
<term>Microwave irradiation</term>
<term>Mini review</term>
<term>Molecule</term>
<term>Mylabris</term>
<term>Mylabris phalerate pallas</term>
<term>Natural derivatives</term>
<term>Natural molecules</term>
<term>Natural products</term>
<term>Natural source</term>
<term>Natural sources</term>
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<term>Nctd analogs</term>
<term>Nctd derivatives</term>
<term>Negative impact</term>
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<term>Norcantharimide analogs</term>
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<term>Pharmacological information</term>
<term>Phosphatase</term>
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<term>Poor diene</term>
<term>Poor yields</term>
<term>Possible biosynthesis</term>
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<term>Previous works</term>
<term>Primary amines</term>
<term>Proc natl acad</term>
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<term>Protein phosphatase</term>
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<front><div type="abstract">Chemical and pharmacological information on cantharidin‐based small molecules was analyzed. The review summarizes new facts about blister beetles' metabolites for the period 2006–2012. General synthetic approaches to cantharidin‐based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.</div>
<div type="abstract">Chemical and pharmacological information on cantharidin‐based SMs was analyzed. The review summarizes new facts about blister beetles metabolites for the period 2006–2012. General synthetic approaches to cantharidin‐based small molecules as well as its chemical transformations and potential biological applications were discussed in this mini review that could help to design new SMs modulators from other biological models.</div>
</front>
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<tree><country name="Colombie"><noRegion><name sortKey="Puerto Galvis, Carlos E" sort="Puerto Galvis, Carlos E" uniqKey="Puerto Galvis C" first="Carlos E." last="Puerto Galvis">Carlos E. Puerto Galvis</name>
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<name sortKey="Kouznetsov, Vladimir V" sort="Kouznetsov, Vladimir V" uniqKey="Kouznetsov V" first="Vladimir V." last="Kouznetsov">Vladimir V. Kouznetsov</name>
<name sortKey="Vargas Mendez, Leonor Y" sort="Vargas Mendez, Leonor Y" uniqKey="Vargas Mendez L" first="Leonor Y." last="Vargas Méndez">Leonor Y. Vargas Méndez</name>
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